ABSTRACT
Objective To investigate the influence and clinical significance of desensitization therapy on pe-ripheral blood type Ⅱ innate lymphocytes(ILC2s)in children patients with bronchial asthma.Methods 30 children patients with bronchial asthma in this hospital from January 2014 to December 2015 were selected and randomly divided into the simple medication treatment group(n=15)and medication combined desensitization treatment group(n=15),meanwhile 15 healthy children undergoing physical examination were selected as the control group.The flow cytometry and enzyme-linked immunosorbent assay were used to detect peripheral blood ILC2 and IL-13,IL-15,IL-33 expression levels before and after treatment.Results The peripheral blood ILC2s level in the simple medication treatment group and medication combined desensitization treatment group was significantly higher than that in the control group(P<0.05);the peripheral blood ILC2s level after 1-year treatment in the simple medication treatment was still higher than that in the control group(P<0.05);the pe-ripheral blood ILC2s level after 2-month treatment in the medication combined desensitization treatment group was decreased compared with before treatment(P<0.05),which had no statistical difference compared with the control group(P>0.05).The peripheral blood IL-5,IL-13 and IL-33 levels in the simple medication treat-ment group and medication combined desensitization treatment group were significantly higher than those in the control group(P<0.05).The peripheral blood IL-5,IL-13 and IL-33 levels after 1-year treatment in the simple medication treatment group were still higher than those in the control group(P<0.05);the peripheral